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Testing Data

SCGF- alpha active protein

Human SCGF- alpha

Gene Names
CLEC11A; P47; SCGF; LSLCL; CLECSF3
Reactivity
Species Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
SCGF- alpha; Human SCGF- alpha; Recombinant Human SCGF- alpha; SCGF- alpha active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
GHGARGAER EWEGGWGGA QEEEREREA LMLKHLQEA LGLPAGRGD ENPAGTVEG KEDWEMEED QGEEEEEEA TPTPSSGPS PSPTPEDIV TYILGRLAG LDAGLHQLH VRLHALDTR VVELTQGLR QLRNAAGDT RDAVQALQE AQGRAEREH GRLEGCLKG LRLGHKCFL LSRDFEAQA AAQARCTAR GGSLAQPAD RQQMEALTR YLRAALAPY NWPVWLGVH DRRAEGLYL FENGQRVSF FAWHRSPRP ELGAQPSAS PHPLSPDQP NGGTLENCV AQASDDGSW WDHDCQRRL YYVCEFPF
Biological Activity
Determined by its inhibitory effect on the proliferation of TF-1 cells previously grown in media containing GM-CSF. The ED50 for this effect was observed at 2.5 ng/ml.
Cell Type
Stem Cells
Preparation and Storage
At -20 degree C

Testing Data

Testing Data
Related Product Information for SCGF- alpha active protein
SCGF- alpha and -beta are hematopoietic growth factor that exerts their activity at early stages of hematopoiesis. The SCGFs are non-glycosylated species-specific cytokines that can support growth of primitive hematopoietic cells, and in combination with EPO or GM-CSF, promote proliferation or erthroid or myeloid progenitors, respectively. Recombinant human SCGF- alpha is a 33.9 kDa polypeptide containing 305 amino acid residues.
Product Categories/Family for SCGF- alpha active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
35,695 Da
NCBI Official Full Name
C-type lectin domain family 11 member A
NCBI Official Synonym Full Names
C-type lectin domain family 11, member A
NCBI Official Symbol
CLEC11A
NCBI Official Synonym Symbols
P47; SCGF; LSLCL; CLECSF3
NCBI Protein Information
C-type lectin domain family 11 member A; stem cell growth factor; lymphocyte secreted C-type lectin; C-type lectin superfamily member 3; lymphocyte secreted long form of C-type lectin; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3
UniProt Protein Name
C-type lectin domain family 11 member A
UniProt Gene Name
CLEC11A
UniProt Synonym Gene Names
CLECSF3; LSLCL; SCGF
UniProt Entry Name
CLC11_HUMAN

NCBI Description

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

CLEC11A: Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: growth factor activity; carbohydrate binding

Biological Process: positive regulation of cell proliferation

Research Articles on SCGF- alpha

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Product Notes

The SCGF- alpha clec11a (Catalog #AAA695773) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human SCGF- alpha reacts with Species Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: GHGARGAER EWEGGWGGA QEEEREREA LMLKHLQEA LGLPAGRGD ENPAGTVEG KEDWEMEED QGEEEEEEA TPTPSSGPS PSPTPEDIV TYILGRLAG LDAGLHQLH VRLHALDTR VVELTQGLR QLRNAAGDT RDAVQALQE AQGRAEREH GRLEGCLKG LRLGHKCFL LSRDFEAQA AAQARCTAR GGSLAQPAD RQQMEALTR YLRAALAPY NWPVWLGVH DRRAEGLYL FENGQRVSF FAWHRSPRP ELGAQPSAS PHPLSPDQP NGGTLENCV AQASDDGSW WDHDCQRRL YYVCEFPF. It is sometimes possible for the material contained within the vial of "SCGF- alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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