PlGF-3 active protein
Human PlGF-3
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
Uniprot Description
Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Ref.8
Subunit structure: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Isoform PlGF-3 is found both as homodimer and as monomer.
Subcellular location: Secreted. Note: The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Domain: Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.
Post-translational modification: N-glycosylated.
Sequence similarities: Belongs to the PDGF/VEGF growth factor family.
Research Articles on PlGF-3
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Product Notes
The PlGF-3 pgf (Catalog #AAA691544) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human PlGF-3 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSE YPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK I RSGDRPSYV ELTFSQHVRC ECRHSPGRQS PDMPGDFRAD APSFLPP RRS LPMLFRMEWG CALTGSQSAV WPSSPVPEEI PRMHPGRNGK KQ QRKPLREK MKPERCGDAV PRR. It is sometimes possible for the material contained within the vial of "PlGF-3, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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