NOV active protein

Human NOV

Cat. Num. AAA691519

• Gene Names: PLXNA1; NOV; NOVP; PLXN1; PLEXIN-A1
• Reactivity: Human
• Purity: 95 % (SDS-PAGE, HPLC)
• Synonyms: NOV; Human NOV; Recombinant Human NOV; NOV active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: 95 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: MQVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRG ESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI Y RSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEV PGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IE QTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPE QP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGR CCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFL Q ELELKTTRGK M
• Sequence Length: 1896

• Endotoxin Level: < 0.1 ng per ug of NOV
• Biological Activity: Determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 ug/ml

Related Product Information for NOV active protein

NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

Product Categories/Family for NOV active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 262118282
• NCBI GeneID: 5361
• NCBI Accession #: NP_115618.3
• NCBI GenBank Nucleotide #: NM_032242.3
• UniProt Accession #: Q9UIW2
• Molecular Weight: 36.2 kDa
• NCBI Official Full Name: plexin-A1
• NCBI Official Synonym Full Names: plexin A1
• NCBI Official Symbol: PLXNA1
• NCBI Official Synonym Symbols: NOV; NOVP; PLXN1; PLEXIN-A1
• NCBI Protein Information: plexin-A1; plexin 1; semaphorin receptor NOV
• UniProt Protein Name: Plexin-A1
• Protein Family: Novel plant
• UniProt Gene Name: PLXNA1
• UniProt Synonym Gene Names: NOV; PLXN1
• UniProt Entry Name: PLXA1_HUMAN

Uniprot Description

Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm

By similarity.

Subunit structure: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2

By similarity.

Subcellular location: Cell membrane

Probable; Single-pass type I membrane protein

By similarity.

Tissue specificity: Detected in fetal brain, lung, liver and kidney. Ref.2

Sequence similarities: Belongs to the plexin family.Contains 4 IPT/TIG domains.Contains 1 Sema domain.