NGF-beta active protein
Human NGF-beta
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
Subunit structure: Homodimer.
Subcellular location: Secreted.
Involvement in disease: Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the NGF-beta family.
Sequence caution: The sequence AAH32517.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on NGF-beta
Similar Products
Product Notes
The NGF-beta ngf (Catalog #AAA691531) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human NGF-beta reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINN SVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL T MDGKQAAWR FIRIDTACVC VLSRKAVRRA. It is sometimes possible for the material contained within the vial of "NGF-beta, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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