Maspin (SerpinB5) Active Protein | SerpinB5 active protein
Human Maspin (SerpinB5)
Gene Names
SERPINB5; PI5; maspin
Reactivity
Human
Purity
97 % (SDS-PAGE, HPLC)
Synonyms
Maspin (SerpinB5); Human Maspin (SerpinB5); Recombinant Human Maspin; SerpinB5 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
97 % (SDS-PAGE, HPLC)
Form/Format
Lyophilized
Sequence
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGA KGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK R LYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIK DLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KE CPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSM FI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSI PKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVI H KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTR NIIFFG KFCSP
Sequence Length
375
Endotoxin Level
< 0.1 ng per ug of Maspin
Biological Activity
Data not available.
Related Product Information for SerpinB5 active protein
Maspin (mammary serine protease inhibitor) is a non-inhibitory serpin that is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas. It has the ability to block the growth, invasiveness, and metastatic potential of breast and lung tumors. This anti-tumor activity is achieved, in part, by the ability of Maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells. Recombinant human Maspin is a 42.2 kDa non-glycosylated protein containing 375 amino acid residues.
Product Categories/Family for SerpinB5 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
42.2 kDa
NCBI Official Full Name
serpin B5
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Symbol
SERPINB5
NCBI Official Synonym Symbols
PI5; maspin
NCBI Protein Information
serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
UniProt Protein Name
Serpin B5
Protein Family
UniProt Gene Name
SERPINB5
UniProt Synonym Gene Names
PI5; PI-5
UniProt Entry Name
SPB5_HUMAN
Uniprot Description
Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Subunit structure: Interacts with IRF6. Ref.7
Subcellular location: Secreted › extracellular space.
Tissue specificity: Normal mammary epithelial cells.
Sequence similarities: Belongs to the serpin family. Ov-serpin subfamily.
Research Articles on SerpinB5
Similar Products
Product Notes
The SerpinB5 serpinb5 (Catalog #AAA692104) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Maspin (SerpinB5) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGA KGDT ANEIGQVLHF ENVKDIPFGF QTVTSDVNKL SSFYSLKLIK R LYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIK DLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFPESET KE CPFRLNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSM FI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSI PKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVI H KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTR NIIFFG KFCSP. It is sometimes possible for the material contained within the vial of "Maspin (SerpinB5), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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