IL-36 alpha active protein

Human IL-36 alpha (IL-1F6)

Cat. Num. AAA692490

• Gene Names: IL36A; FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
• Reactivity: Human
• Purity: >985 by SDS-PAGE and HPLC analyses
• Synonyms: IL-36 alpha; Human IL-36 alpha (IL-1F6); IL-36 alpha (IL-1F6); Interleukin-36alpha; IL36A; Interleukin-1 family member 6 (IL-1F6); FIL1epsilon (FIL1E); Interleukin-1epsilon (IL1E); IL-36 alpha active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >985 by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGV IGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW S TEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSS PDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TL PIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVE VS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFL VEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS
• Sequence Length: 158

• Biological Activity: Measured by its ability to inhibit secretion of IL-8 by A431 cells in the prescence of IL-36gamma.

Related Product Information for IL-36 alpha active protein

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36alpha (IL-1F6), beta (IL-1F8), and gamma (IL-1F9). IL-36alpha is highly expressed in psoriatic plaques, as are IL-36beta and IL-36gamma, and is the only IL-1 family member found to be expressed by T-cells, as well as monocytes and B-cells. Primarily found in skin and lymphoid tissues, IL-36alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36alpha is a 17.2 kDa protein containing 154 amino acid residues.

Product Categories/Family for IL-36 alpha active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 7657092
• NCBI GeneID: 27179
• NCBI Accession #: NP_055255.1
• NCBI GenBank Nucleotide #: NM_014440.2
• UniProt Accession #: Q9UHA7; Q53SR7; Q5BLR4; Q7RTZ8; B2RAD9
• Molecular Weight: 17,684 Da
• NCBI Official Full Name: interleukin-36 alpha
• NCBI Official Synonym Full Names: interleukin 36 alpha
• NCBI Official Symbol: IL36A
• NCBI Official Synonym Symbols: FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)
• NCBI Protein Information: interleukin-36 alpha
• UniProt Protein Name: Interleukin-36 alpha
• UniProt Gene Name: IL36A
• UniProt Synonym Gene Names: FIL1E; IL1E; IL1F6; IL-1 epsilon; IL-1F6

NCBI Description

The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]

Uniprot Description

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.