IL-20 active protein
Human IL-20
Gene Names
IL20; IL-20; IL10D; ZCYTO10
Reactivity
Human
Purity
> 97% by SDS-PAGE and HPLC analysis
Synonyms
IL-20; Human IL-20; Recombinant Human IL-20; IL-20 active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 97% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTE SLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA N SFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVK ALG ELDILLQWME ETE
Sequence Length
176
Endotoxin Level
< 0.1 ng per ug of IL-20
Biological Activity
Determined by its ability to activate STAT following receptor ligand interaction.
Related Product Information for IL-20 active protein
IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-alpha and type II IL-20R-beta. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.
Product Categories/Family for IL-20 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
35.2 kDa
NCBI Official Full Name
interleukin-20
NCBI Official Synonym Full Names
interleukin 20
NCBI Official Symbol
IL20
NCBI Official Synonym Symbols
IL-20; IL10D; ZCYTO10
NCBI Protein Information
interleukin-20; cytokine Zcyto10; four alpha helix cytokine
UniProt Protein Name
Interleukin-20
UniProt Gene Name
IL20
UniProt Synonym Gene Names
ZCYTO10; IL-20
UniProt Entry Name
IL20_HUMAN
NCBI Description
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3.
Subcellular location: Secreted.
Tissue specificity: Expressed at very low levels in skin, trachea, and other tissues.
Sequence similarities: Belongs to the IL-10 family.
Research Articles on IL-20
Similar Products
Product Notes
The IL-20 il20 (Catalog #AAA691859) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-20 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MLKTLNLGSC VIATNLQEIR NGFSEIRGSV QAKDGNIDIR ILRRTE SLQD TKPANRCCLL RHLLRLYLDR VFKNYQTPDH YTLRKISSLA N SFLTIKKDL RLCHAHMTCH CGEEAMKKYS QILSHFEKLE PQAAVVK ALG ELDILLQWME ETE. It is sometimes possible for the material contained within the vial of "IL-20, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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