IGF-BP7 active protein
Human IGF-BP7
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Uniprot Description
Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Ref.8 Ref.10
Subunit structure: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear.
Subcellular location: Secreted.
Post-translational modification: N-glycosylated. Ref.10
Involvement in disease: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]: An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13
Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 Kazal-like domain.
RNA editing: Edited at positions 78 and 95.Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%. Ref.1 Ref.12
Research Articles on IGF-BP7
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Product Notes
The IGF-BP7 igfbp7 (Catalog #AAA691503) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IGF-BP7 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCG GGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR Y PVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIV TPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT EL LPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQ GQ ASASAKITVV DALHEIPVKK GEGAEL. It is sometimes possible for the material contained within the vial of "IGF-BP7, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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