IFN-lambda1 (IL-29) active protein

Human IFN-lambda1 (IL-29)

Cat. Num. AAA691987

• Gene Names: IFNL1; IL29; IL-29
• Reactivity: Human
• Purity: > 98% by SDS-PAGE and HPLC analysis
• Synonyms: IFN-lambda1 (IL-29); Human IFN-lambda1 (IL-29); Recombinant Human IFN lambda-1; IFN-lambda1 (IL-29) active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 98% by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSC SSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED V LDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKK ESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
• Sequence Length: 200

• Endotoxin Level: < 0.1 ng per ug of IFN lambda-1
• Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.

Related Product Information for IFN-lambda1 (IL-29) active protein

IFN lambda-1,-2, and -3 are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-lambdaR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I interferons (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-lambda 1 is a 19.8 kDa protein containing 178 amino acid residues.

Product Categories/Family for IFN-lambda1 (IL-29) active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 26024325
• NCBI GeneID: 282618
• NCBI Accession #: NP_742152.1
• NCBI GenBank Nucleotide #: NM_172140.1
• UniProt Accession #: Q8IU54; Q17R34; A0AV25
• Molecular Weight: 19.8 kDa
• NCBI Official Full Name: interferon lambda-1
• NCBI Official Synonym Full Names: interferon, lambda 1
• NCBI Official Symbol: IFNL1
• NCBI Official Synonym Symbols: IL29; IL-29
• NCBI Protein Information: interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)
• UniProt Protein Name: Interferon lambda-1
• UniProt Gene Name: IFNL1
• UniProt Synonym Gene Names: IL29; ZCYTO21; IFN-lambda-1; IL-29
• UniProt Entry Name: IFNL1_HUMAN

NCBI Description

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

Subcellular location: Secreted.

Induction: By viral infections or double-stranded RNA.

Sequence similarities: Belongs to the lambda interferon family.