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Betacellulin Active Protein | BTC active protein

Human Betacellulin

Reactivity
Human
Purity
98 % (SDS-PAGE, HPLC)
Synonyms
Betacellulin; Human Betacellulin; Recombinant Human Betacellulin; BTC active protein
Ordering
For Research Use Only!
Host
E Coli
Reactivity
Human
Purity/Purification
98 % (SDS-PAGE, HPLC)
Form/Format
Lyophilized
Sequence
DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYC IKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
Sequence Length
178
Endotoxin Level
< 0.1 ng per ug of Betacellulin
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107units/mg.
Related Product Information for BTC active protein
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Product Categories/Family for BTC active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
685
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
9.0 kDa
NCBI Official Full Name
probetacellulin
NCBI Official Synonym Full Names
betacellulin
NCBI Official Symbol
BTC
NCBI Protein Information
probetacellulin
UniProt Protein Name
Probetacellulin
Protein Family
UniProt Gene Name
BTC
UniProt Synonym Gene Names
BTC
UniProt Entry Name
BTC_HUMAN

NCBI Description

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Ref.5

Subunit structure: Monomer. Interacts with EGFR and ERBB4. Ref.5 Ref.6

Subcellular location: Betacellulin: Secreted › extracellular space. Probetacellulin: Cell membrane; Single-pass type I membrane protein.

Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. Ref.4

Sequence similarities: Contains 1 EGF-like domain.

Research Articles on BTC

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Product Notes

The BTC btc (Catalog #AAA691789) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Betacellulin reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYC IKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY. It is sometimes possible for the material contained within the vial of "Betacellulin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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