BD-4 active protein

Human BD-4

Cat. Num. AAA692149

• Gene Names: DEFB104B; BD-4; hBD-4; DEFB-4
• Reactivity: Human
• Purity: 98 % (SDS-PAGE, HPLC)
• Synonyms: BD-4; Human BD-4; Recombinant Human BD-4; BD-4 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: 98 % (SDS-PAGE, HPLC)
• Form/Format: Lyophilized
• Sequence: EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLN RTKP
• Sequence Length: 72

• Endotoxin Level: < 0.1 ng per ug of BD-4
• Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100.0 ng/ml.

Related Product Information for BD-4 active protein

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemo attractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.

Product Categories/Family for BD-4 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 103485137
• NCBI GeneID: 503618
• NCBI Accession #: NP_001035792.1
• NCBI GenBank Nucleotide #: NM_001040702.1
• UniProt Accession #: Q8WTQ1; Q496I2; Q496I3; Q496I4
• Molecular Weight: 6.0 kDa
• NCBI Official Full Name: beta-defensin 104
• NCBI Official Synonym Full Names: defensin, beta 104B
• NCBI Official Symbol: DEFB104B
• NCBI Official Synonym Symbols: BD-4; hBD-4; DEFB-4
• NCBI Protein Information: beta-defensin 104; beta-defensin 4; defensin, beta 104
• UniProt Protein Name: Beta-defensin 104
• UniProt Gene Name: DEFB104A
• UniProt Synonym Gene Names: DEFB104; DEFB4; BD-4; DEFB-4; hBD-4
• UniProt Entry Name: D104A_HUMAN

NCBI Description

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Ref.1

Subcellular location: Secreted.

Tissue specificity: High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested. Ref.1

Induction: Antimicrobial activity is decreased when the sodium chloride concentration is increased.

Sequence similarities: Belongs to the beta-defensin family.