FK506 Binding Protein Like Active Protein | FKBPL active protein

Recombinant Human FK506 Binding Protein Like

Cat. Num. AAA143986

• Gene Names: FKBPL; NG7; DIR1; WISP39
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: FK506 Binding Protein Like; Recombinant Human FK506 Binding Protein Like; FKBPL Human; FK506 Binding Protein Like Human Recombinant; WISP39; DIR1; NG7; FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; FKBPL; FKBPL active protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: FKBPL Human solution containing 20mM Trsi pH-8, 2mM DTT, 0.1M NaCl & 20% glycerol.; Sterile filtered colorless solution.
• Sequence: METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFGL EHHHHHH
• Sequence Length: 349

• Biological Activity: Specific activity is > 210 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
• Preparation and Storage: FKBPL Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for FKBPL active protein

Description: FKBPL Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-349 a.a.) and having a molecular mass of 39.2 kDa. The FKBPL is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

Introduction: FKBPL is related to the immunophilin protein family, which take part in immunoregulation and regular cellular processes involving protein folding and trafficking. FKBPL has an important function in the induced radioresistance and participates in the control of the cell cycle. FKBPL has a role in cellular response to stress. FKBPL interacts with Hsp90, glucocorticoid receptor and dynamitin and is involved in signalling, like other FKBPs.

Product Categories/Family for FKBPL active protein

Enzymes; FK506 Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 17149853
• NCBI GeneID: 63943
• NCBI Accession #: NP_071393.2
• NCBI GenBank Nucleotide #: NM_022110.3
• UniProt Accession #: Q9UIM3; Q9H5G3; A8K5V3; B0UYX8
• Molecular Weight: 38,176 Da
• NCBI Official Full Name: FK506-binding protein-like
• NCBI Official Synonym Full Names: FK506 binding protein like
• NCBI Official Symbol: FKBPL
• NCBI Official Synonym Symbols: NG7; DIR1; WISP39
• NCBI Protein Information: FK506-binding protein-like; FK506-binding protein like; WAF-1/CIP1 stabilizing protein 39
• UniProt Protein Name: FK506-binding protein-like
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBPL
• UniProt Synonym Gene Names: DIR1; NG7; WISp39
• UniProt Entry Name: FKBPL_HUMAN

NCBI Description

The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

Uniprot Description

FKBPL: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: endoplasmic reticulum membrane

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity

Biological Process: response to radiation; protein peptidyl-prolyl isomerization