FK506 Binding Protein 1B Active Protein | FKBP1B active protein

Recombinant Human FK506 Binding Protein 1B

Cat. Num. AAA144978

• Gene Names: FKBP1B; OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6
• Purity: Greater than 90.0% as determined by SDS-PAGE analysis.
• Synonyms: FK506 Binding Protein 1B; Recombinant Human FK506 Binding Protein 1B; FKBP1B Human; FK506 Binding Protein 1B Human Recombinant; Peptidyl-prolyl cis-trans isomerase FKBP1B; PPIase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12; FKBP1B; FKBP12.6; FKBP1L; FKBP9; OTK4; FKBP1B active protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE analysis.
• Form/Format: The FKBP1B solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE.
• Sequence Length: 108

• Biological Activity: Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for FKBP1B active protein

Description: FKBP1B Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-108) and having a molecular mass of 14.2kDa.FKBP1B is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.

Product Categories/Family for FKBP1B active protein

Enzymes; FK506 Binding Protein

NCBI and Uniprot Product Information

• NCBI GI #: 4758380
• NCBI GeneID: 2281
• NCBI Accession #: NP_004107.1
• NCBI GenBank Nucleotide #: NM_004116.3
• UniProt Accession #: P68106; Q13664; Q16645; Q53TM2; Q9BQ40
• Molecular Weight: 8,802 Da
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP1B isoform a
• NCBI Official Synonym Full Names: FK506 binding protein 1B, 12.6 kDa
• NCBI Official Symbol: FKBP1B
• NCBI Official Synonym Symbols: OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; PPIase FKBP1B; calstabin 2; h-FKBP-12; immunophilin FKBP12.6; rotamase
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP1B
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: FKBP1B
• UniProt Synonym Gene Names: FKBP12.6; FKBP1L; FKBP9; OTK4; PPIase FKBP1B; 12.6 kDa FKBP; FKBP-12.6; FKBP-1B
• UniProt Entry Name: FKB1B_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: sarcoplasmic reticulum membrane; membrane; cytoplasm; Z disc; cytosol

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; cyclic nucleotide binding; calcium channel inhibitor activity; ryanodine-sensitive calcium-release channel activity; receptor binding

Biological Process: positive regulation of sequestering of calcium ion; positive regulation of axon regeneration; protein maturation via protein folding; protein peptidyl-prolyl isomerization; cytosolic calcium ion homeostasis; negative regulation of heart rate; response to redox state; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; T cell proliferation; negative regulation of protein phosphatase type 2B activity; response to vitamin E; smooth muscle contraction; 'de novo' protein folding; response to hydrogen peroxide; insulin secretion; negative regulation of release of sequestered calcium ion into cytosol; action potential propagation; response to glucose stimulus; protein refolding; transmembrane transport