Ubiquitin-Associated Domain-Containing Protein 1 (UBAC1) Active Protein | UBAC1 active protein

Recombinant Human Ubiquitin-Associated Domain-Containing Protein 1 (UBAC1) (Active)

Cat. Num. AAA7135729

• Gene Names: UBAC1; KPC2; GBDR1; UBADC1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ubiquitin-Associated Domain-Containing Protein 1 (UBAC1); Recombinant Human Ubiquitin-Associated Domain-Containing Protein 1 (UBAC1) (Active); E3 ubiquitin-protein ligase subunit KPC2; Glialblastoma cell differentiation-related protein 1; Kip1 ubiquitination-promoting complex protein 2; UBA domain-containing protein 1; GBDR1; KPC2; UBADC1; UBAC1 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid or Lyophilized Powder; If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.; If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, p
• Sequence Positions: 1-405aa; Full Length
• Sequence: MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT
• Sequence Length: 405

• Species: Human
• Tag: N-terminal GST-tagged
• Endotoxin: Not test.
• Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized CCL5 at 2 ug/ml can bind human UBAC1, the EC50 of human UBAC1 protein is 86.67-97.25 ug/ml.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Preparation and Storage: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for UBAC1 active protein

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Product Categories/Family for UBAC1 active protein

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 55770884
• NCBI GeneID: 10422
• NCBI Accession #: NP_057256.2
• NCBI GenBank Nucleotide #: NP_057256.2
• UniProt Accession #: Q9BSL1
• Molecular Weight: 72.3 kDa
• NCBI Official Full Name: ubiquitin-associated domain-containing protein 1
• NCBI Official Synonym Full Names: UBA domain containing 1
• NCBI Official Symbol: UBAC1
• NCBI Official Synonym Symbols: KPC2; GBDR1; UBADC1
• NCBI Protein Information: ubiquitin-associated domain-containing protein 1
• UniProt Protein Name: Ubiquitin-associated domain-containing protein 1
• Protein Family: Ubiquitin-associated domain-containing protein
• UniProt Gene Name: UBAC1
• UniProt Synonym Gene Names: GBDR1; KPC2; UBADC1; UBA domain-containing protein 1
• UniProt Entry Name: UBAC1_HUMAN

Uniprot Description

UBAC1: Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: Golgi apparatus; cytoplasm; plasma membrane

Molecular Function: protein binding

Biological Process: protein ubiquitination