Twisted Gastrulation Protein Active Protein | TWSG1 active protein

Twisted Gastrulation Protein, Recombinant, Human (TSG)

Gene Names

TWSG1; TSG

Purity

Highly Purified
98% by SDS-PAGE and HPLC analyses.

Synonyms

Twisted Gastrulation Protein; Recombinant; Human (TSG); TWSG1 active protein

Ordering
Cat. Num. AAA650562 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

E Coli

Purity/Purification

Highly Purified
98% by SDS-PAGE and HPLC analyses.

Form/Format

Supplied as a lyophilized powder in 10mM sodium acetate, pH6.0. Reconcentrate with dH2O, carrier protein to a concentration of 0.1-1mg/ml.

Biological Activity

Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is < 2.0 mg/ml of TSG.

Country of Origin

USA

Preparation and Storage

Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile dH2O, carrier protein, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for TWSG1 active protein

Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 199 amino acid 22kD protein containing the BMP/TGF binding portion of the full length TSG protein.

Product Categories/Family for TWSG1 active protein

Growth Factors; Cytokines; Growth Factors-Other

NCBI and Uniprot Product Information

NCBI GI #

10190664

NCBI GeneID

57045

NCBI Accession #

NP_065699.1

NCBI GenBank Nucleotide #

NM_020648.5

UniProt Accession #

Q9GZX9; Q8NBI7; Q96K46; B2RE08; D3DUH9

Molecular Weight

22kD

NCBI Official Full Name

twisted gastrulation protein homolog 1

NCBI Official Synonym Full Names

twisted gastrulation homolog 1 (Drosophila)

NCBI Official Symbol

TWSG1

NCBI Official Synonym Symbols

TSG

NCBI Protein Information

twisted gastrulation protein homolog 1; OTTHUMP00000162352

UniProt Protein Name

Twisted gastrulation protein homolog 1

Protein Family

Twisted gastrulation protein

UniProt Gene Name

TWSG1

UniProt Synonym Gene Names

TSG

UniProt Entry Name

TWSG1_HUMAN

Uniprot Description

Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development

Subunit structure: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7

Subcellular location: Secreted

Developmental stage: Expressed in brain throughout development. Ref.3

Domain: The N-terminal domain is sufficient to interact with BMP4

Sequence similarities: Belongs to the twisted gastrulation protein family.

Research Articles on TWSG1

1. mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies

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Product Notes

The TWSG1 twsg1 (Catalog #AAA650562) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Twisted Gastrulation Protein, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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