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PRL-1 active protein

PRL-1 (human), (recombinant) (His-tag)

Gene Names
PTP4A1; HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
Purity
>=75% (SDS-PAGE)
Synonyms
PRL-1; PRL-1 (human); (recombinant) (His-tag); PRL-1 active protein
Ordering
For Research Use Only!
Host
E Coli
Purity/Purification
>=75% (SDS-PAGE)
Form/Format
Liquid. In 40mM TRIS-HCl, pH8.0, containing 110mM sodium chloride, potassium chloride, 200mM imidazole, 20% glycerol and 3mM DTT
Source Note
The catalytic domain of PRL-1 (aa 2-173) is fused at the N-terminus to a His-tag
Specific Activity
>=0.168U/min/ug. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37 degree C. Assay buffer: 50mM TRIS, pH7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
For long term storage, store at -80 degree C
Dilution of the enzyme followed by refreezing may lead to loss of activity
Shipping: Shipped on Dry Ice
Related Product Information for PRL-1 active protein
PRL phosphatases comprise a class of small oncogenic phosphatases that are prenylated at their carboxyl-termini. PRL-1 is overexpressed during cell proliferation in the liver and during differentiation of epithelial cells in the digestive tract. It augments MMP-2 and MMP-9 expression, which in turn induce cell migration and invasion.
Product Categories/Family for PRL-1 active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19,815 Da
NCBI Official Full Name
protein tyrosine phosphatase type IVA 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase type IVA, member 1
NCBI Official Symbol
PTP4A1
NCBI Official Synonym Symbols
HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)
NCBI Protein Information
protein tyrosine phosphatase type IVA 1; protein tyrosine phosphatase type IVA protein 1; protein-tyrosine phosphatase 4a1; protein-tyrosine phosphatase of regenerating liver 1
UniProt Protein Name
Protein tyrosine phosphatase type IVA 1
UniProt Gene Name
PTP4A1
UniProt Synonym Gene Names
PRL1; PTPCAAX1; PRL-1
UniProt Entry Name
TP4A1_HUMAN

NCBI Description

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Uniprot Description

PTP4A1: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. Belongs to the protein-tyrosine phosphatase family.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q12

Cellular Component: internal side of plasma membrane; endoplasmic reticulum; early endosome; cytoplasm; spindle

Molecular Function: protein tyrosine phosphatase activity

Biological Process: multicellular organismal development; cell cycle; positive regulation of cell migration

Research Articles on PRL-1

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Product Notes

The PRL-1 ptp4a1 (Catalog #AAA566697) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PRL-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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