PKA alpha Active Protein | Prkaca active protein
PKA alpha (catalytic domain) (mouse), (recombinant)
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NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine/threonine protein kinase family. The holoenzyme, protein kinase A (also known as cyclic-AMP dependent protein kinase), mediates cellular response to changes in cyclic-AMP levels. This gene encodes the alpha catalytic subunit of protein kinase A. Protein kinase A-mediated signaling is transduced via phosphorylation of target proteins, and is important for many cellular functions, including mammalian sperm maturation and motility. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Apr 2013]
Uniprot Description
PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.
Protein type: Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.11; AGC group; PKA family
Cellular Component: Golgi apparatus; centrosome; neuron projection; protein complex; mitochondrion; cilium; cAMP-dependent protein kinase complex; cell projection; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleus; neuromuscular junction; AMP-activated protein kinase complex
Molecular Function: cAMP-dependent protein kinase activity; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; protein complex binding; kinase activity; ATP binding; Rab GTPase binding
Biological Process: regulation of synaptic transmission; regulation of synaptic transmission, glutamatergic; regulation of osteoblast differentiation; protein amino acid autophosphorylation; peptidyl-threonine phosphorylation; negative regulation of meiotic cell cycle; protein amino acid phosphorylation; regulation of cellular respiration; positive regulation of protein export from nucleus; peptidyl-serine phosphorylation; mesoderm formation; neural tube closure; positive regulation of cell proliferation; phosphorylation; sperm capacitation
Research Articles on Prkaca
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Product Notes
The Prkaca prkaca (Catalog #AAA566588) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PKA alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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