Lymphotactin protein (XCL1) Active Protein | XCL1 active protein

Recombinant Human Lymphotactin protein (XCL1) (Active)

Cat. Num. AAA969197

• Gene Names: XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Lymphotactin protein (XCL1); Recombinant Human Lymphotactin protein (XCL1) (Active); ATAC; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XCL1 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Positions: 23-114aa
• Sequence: GSEVSDKRTC VSLTTQRLPV SRIKTYTITE GSLRAVIFIT KRGLKVCADP QATWVRDVVR SMDRKSNTRN NMIQTKPTGT QQSTNTAVTL TG
• Sequence Length: 114

• Species: Homo sapiens (Human)
• Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 10-100 ng/ml.
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Protein Note: Protein will be provided with aseptic processing and endotoxin removal.
• Preparation and Storage: Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

SDS-PAGE

Related Product Information for XCL1 active protein

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Product Categories/Family for XCL1 active protein

Biological Active Protein; Immunology; Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 4506853
• NCBI GeneID: 6375
• NCBI Accession #: NP_002986.1
• NCBI GenBank Nucleotide #: NM_002995.2
• UniProt Accession #: P47992; Q52MA8
• Molecular Weight: 10.2 kDa
• NCBI Official Full Name: lymphotactin
• NCBI Official Synonym Full Names: X-C motif chemokine ligand 1
• NCBI Official Symbol: XCL1
• NCBI Official Synonym Symbols: LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• NCBI Protein Information: lymphotactin
• UniProt Protein Name: Lymphotactin
• Protein Family: Lymphotactin
• UniProt Gene Name: XCL1
• UniProt Synonym Gene Names: LTN; SCYC1

NCBI Description

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

Uniprot Description

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; protein homodimerization activity

Biological Process: cell-cell signaling; G-protein coupled receptor protein signaling pathway; monocyte chemotaxis; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of T cell cytokine production; negative regulation of T-helper 1 type immune response; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of interleukin-10 production; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; regulation of inflammatory response; release of sequestered calcium ion into cytosol; response to virus; signal transduction