Interleukin 6 Active Protein | Il6 active protein

Interleukin 6, Recombinant, Mouse (IL-6)

Cat. Num. AAA650161

• Gene Names: Il6; ILg6; Ifnb2
• Purity: Purified; 98% pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE).
• Synonyms: Interleukin 6; Recombinant; Mouse (IL-6); Il6 active protein

• Host: E Coli
• Purity/Purification: Purified; 98% pure (HPLC, FPLC and reducing and non-reducing SDS-PAGE).
• Form/Format: Supplied as a lyophilized powder from 50mM NH4HCO3, pH 8.0. No preservative added. Reconstitute using 100mM acetic acid to 0.1-1mg/ml.

• Biological Activity: The ED50 as determined by dose-dependent stimulation of mouse 7TD1 is <0.02ng/ml, corresponding to a specific activity of 1x10e7IU/mg.
• Endotoxin Level: 0.1ng/ug
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute with sterile buffer or ddH2O, 0.1% HSA or BSA. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for Il6 active protein

Recombinant mouse IL-6 is a single, non-glycosylated polypeptide chain containing 187aa and having a molecular weight of 21.7kD. The sequence of the first five N-terminal amino acids was determined to be Met-Phe-Pro-Thr-Ser. Contains less than 1% dimers and aggregates.

Product Categories/Family for Il6 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

• NCBI GI #: 7549769
• NCBI GeneID: 24498
• NCBI Accession #: NP_036721.1
• NCBI GenBank Nucleotide #: NM_012589.1
• UniProt Accession #: P20607
• Molecular Weight: ~21.7kD
• NCBI Official Full Name: interleukin-6
• NCBI Official Synonym Full Names: interleukin 6
• NCBI Official Symbol: Il6
• NCBI Official Synonym Symbols: ILg6; Ifnb2
• NCBI Protein Information: interleukin-6; IL-6; Interleukin 6 (interferon, beta 2)
• UniProt Protein Name: Interleukin-6
• Protein Family: Interleukin
• UniProt Gene Name: Il6
• UniProt Synonym Gene Names: Il-6
• UniProt Entry Name: IL6_RAT

NCBI Description

a cytokine involved in development and possibly in neurodegenerative processes [RGD]

Uniprot Description

Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-6 superfamily.