Interleukin 2 Active Protein | IL2 active protein

Interleukin 2, Recombinant, Human (IL-2)

Gene Names

IL2; IL-2; TCGF; lymphokine

Purity

Highly Purified
Purified. 95% pure by SDS gel electrophoresis.

Synonyms

Interleukin 2; Recombinant; Human (IL-2); IL2 active protein

Ordering
Cat. Num. AAA650474 For Research Use Only!

Host

E Coli

Purity/Purification

Highly Purified
Purified. 95% pure by SDS gel electrophoresis.

Form/Format

Supplied as a lyophilized powder from sodium phosphate, SDS, mannitol. Reconstitute with sterile ddH2O.

Biological Activity

The biological activity is determined by a lymphocyte proliferation assay ~160,000 IU (International units).

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Reconstitute to with sterile dH2O, aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for IL2 active protein

Human Interleukin-2 (IL-2) is a lymphokine which biological effects include activation and proliferation of T cells, B cells, and other lymphokine activated killer cells. Human IL-2 is composed of 133aa, including 3 cysteine residues, two of which are involved in a disulfide bond essential for biological activity. Human and murine IL-2 are 62% homologous, and human IL-2 has been found to be active on murine cell lines.

Product Categories/Family for IL2 active protein

Growth Factors; Cytokines; Growth Factors-Interleukin

NCBI and Uniprot Product Information

NCBI GI #

512412

NCBI GeneID

3558

UniProt Accession #

P60568; P01585; Q0GK43; Q13169; Q16334; Q309Q7; Q6NZ91; Q6NZ93; Q6QWN0; Q71V48; Q7Z7M3

Molecular Weight

15kD

NCBI Official Full Name

interleukin-2

NCBI Official Synonym Full Names

interleukin 2

NCBI Official Symbol

IL2

NCBI Official Synonym Symbols

IL-2; TCGF; lymphokine

NCBI Protein Information

interleukin-2; aldesleukin; OTTHUMP00000164090; T cell growth factor; involved in regulation of T-cell clonal expansion

UniProt Protein Name

Interleukin-2

Protein Family

Interleukin

UniProt Gene Name

IL2

UniProt Entry Name

IL2_HUMAN

NCBI Description

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq]

Uniprot Description

Function: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Subcellular location: Secreted.

Involvement in disease: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Pharmaceutical use: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Sequence similarities: Belongs to the IL-2 family.

Sequence caution: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation.

Research Articles on IL2

1. Data show there was a significant decrease in Th1 intracellular cytokines IFNgamma, IL-2 and TNFalpha in the blood of culture positive patients compared with culture negative patients.

Similar Products

Product Notes

The IL2 il2 (Catalog #AAA650474) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Interleukin 2, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.