IGF2 active protein

Recombinant Human IGF2

Cat. Num. AAA4159844

• Gene Names: IGF2; GRDF; IGF-II; PP9974; C11orf43
• Purity: >95% as determined by SDS-PAGE
• Synonyms: IGF2; Recombinant Human IGF2; Insulin-like growth factor II; multiplication stimulating activity; MSA; Somatomedin-A; T3M-11-derived growth factor; PP1446; IGF2 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in Tris and NaCl
• Sequence Length: 180

• Bioactivity: The ED50 as determined by dose dependent proliferation of MCF7 cells was <1ng/ml
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile PBS at 100 ug/mL
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for IGF2 active protein

Insulin-like growth factor 2 (IGF2) is one of the mitogenic, polypeptide growth factors that belongs to the insulin family, due to its structural and functional similarity to insulin. IGF2 is mainly produced in the liver and several other tissues at certain times. IGF2 expression can be found in many tissues usually with autocrine, paracrine and endocrine functions. IGF2 mainly acts as a growth promoting hormone during gestation, and does so by binding to the tyrosine kinase type I receptor (IGF1R) as well as the IGF2 receptor cation-independent mannose 6-phosphate receptor. Mature IGF2 is highly conserved between human, bovine, and porcine species. Recombinant Human IGF2 is a single, non-glycosylated, polypeptide chain of 7.8 kDa.

NCBI and Uniprot Product Information

• NCBI GI #: 124255
• NCBI GeneID: 3481
• UniProt Accession #: P01344
• Molecular Weight: 7.8 kDa
• NCBI Official Full Name: Insulin-like growth factor II
• NCBI Official Synonym Full Names: insulin like growth factor 2
• NCBI Official Symbol: IGF2
• NCBI Official Synonym Symbols: GRDF; IGF-II; PP9974; C11orf43
• NCBI Protein Information: insulin-like growth factor II
• UniProt Protein Name: Insulin-like growth factor II
• Protein Family: Insulin-like growth factor
• UniProt Gene Name: IGF2
• UniProt Synonym Gene Names: IGF-II
• UniProt Entry Name: IGF2_HUMAN

NCBI Description

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]