Ceacam1/BGP-1 protein Active Protein | BGP-1 active protein

Recombinant Rat Ceacam1/BGP-1 protein (His Tag)

Cat. Num. AAA2569446

• Gene Names: Ceacam1; Bgp; BGPR; CD66a; Ccam1
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: Ceacam1/BGP-1 protein; Recombinant Rat Ceacam1/BGP-1 protein (His Tag); Antigen CD66; BGP 1; Biliary glycoprotein 1; CD66a; CEACAM1; meconium antigen 100; Carcinoembryonic antigen-related cell adhesion molecule 1; Biliary glycoprotein D;; MHVR1; Murine hepatitis virus receptor; MHV-R; Bgp1; BGP-1 active protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: 35Q-425A

• Species: Rat
• Tag: N/C-His
• Protein Construction: A DNA sequence encoding the Rat Ceacam1/BGP-1 protein (P16573)(35Q-425A) was expressed with a polyhistidine tag at the N-terminus.
• Activity: Immunogen (E-AB-40353)
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for BGP-1 active protein

Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors.Plays a role in immune response, of T-cells, natural killer (NK) and neutrophils.

NCBI and Uniprot Product Information

• NCBI GI #: 76496477
• NCBI GeneID: 81613
• NCBI Accession #: NP_001029032.1
• NCBI GenBank Nucleotide #: NM_001033860.1
• UniProt Accession #: P16573
• Molecular Weight: 57,264 Da
• NCBI Official Full Name: carcinoembryonic antigen-related cell adhesion molecule 1 isoform 1
• NCBI Official Synonym Full Names: carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
• NCBI Official Symbol: Ceacam1
• NCBI Official Synonym Symbols: Bgp; BGPR; CD66a; Ccam1
• NCBI Protein Information: carcinoembryonic antigen-related cell adhesion molecule 1; GP110; pp120; C-CAM 105; ecto-ATPase; osteocalcin; cell-CAM 105; pp120/ecto-ATPase; ATP-dependent taurocolate-carrier protein; bone gamma-carboxyglutamic acid (Gla) protein; CEA-related cell adhes
• UniProt Protein Name: Carcinoembryonic antigen-related cell adhesion molecule 1
• UniProt Gene Name: Ceacam1
• UniProt Synonym Gene Names: C-CAM 105
• UniProt Entry Name: CEAM1_RAT

NCBI Description

glycoprotein component of bile; plays a role in cell adhesion [RGD, Feb 2006]

Uniprot Description

CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.

Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane; integral to plasma membrane; brush border membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein homodimerization activity; virion binding; protein kinase binding

Biological Process: Peyer's patch development; negative regulation of JNK cascade; entry of virus into host cell; positive regulation of NFAT protein import into nucleus; positive regulation of JNK cascade; positive regulation of immunoglobulin secretion; signal transduction; calcium-independent cell-cell adhesion; negative regulation of interleukin-2 production; positive regulation of MAP kinase activity; negative regulation of T cell proliferation; negative regulation of cytokine production; calcium-dependent cell-cell adhesion; positive regulation of T cell proliferation; homophilic cell adhesion; cell adhesion