C-C motif chemokine 25 protein (Ccl25) Active Protein | Ccl25 active protein

Recombinant Mouse C-C motif chemokine 25 protein (Ccl25) (Active)

Cat. Num. AAA969255

• Gene Names: Ccl25; TECK; CKb15; Scya25; AI852536; A130072A22Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-C motif chemokine 25 protein (Ccl25); Recombinant Mouse C-C motif chemokine 25 protein (Ccl25) (Active); Chemokine TECK; Thymus-expressed chemokine; Ccl25 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Positions: 24-144aa
• Sequence: QGAFEDCCLG YQHRIKWNVL RHARNYHQQE VSGSCNLRAV RFYFRQKVVC GNPEDMNVKR AIRILTARKR LVHWKSASDS QTERKKSNHM KSKVENPNST SVRSATLGHP RMVMMPRKTN N
• Sequence Length: 144

• Species: Mus musculus (Mouse)
• Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-50 ng/ml.
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Protein Note: Protein will be provided with aseptic processing and endotoxin removal.
• Preparation and Storage: Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

SDS-PAGE

Related Product Information for Ccl25 active protein

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Product Categories/Family for Ccl25 active protein

Biological Active Protein; Immunology; Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 6677881
• NCBI GeneID: 20300
• NCBI Accession #: NP_033164.1
• NCBI GenBank Nucleotide #: NM_009138.3
• UniProt Accession #: O35903; Q9QYY6
• Molecular Weight: 14.1 kDa
• NCBI Official Full Name: C-C motif chemokine 25
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 25
• NCBI Official Symbol: Ccl25
• NCBI Official Synonym Symbols: TECK; CKb15; Scya25; AI852536; A130072A22Rik
• NCBI Protein Information: C-C motif chemokine 25
• UniProt Protein Name: C-C motif chemokine 25
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl25
• UniProt Synonym Gene Names: Scya25; Teck

Uniprot Description

CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8 A1.1|8 2.01 cM

Cellular Component: extracellular space

Molecular Function: CCR chemokine receptor binding; CCR10 chemokine receptor binding; chemokine activity; chemokine receptor binding; protein binding

Biological Process: chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; leukocyte migration; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of cell-matrix adhesion; positive regulation of GTPase activity