AKR7A3 active protein

Human Recombinant AKR7A3

Cat. Num. AAA845376

• Gene Names: AKR7A3; AFAR2
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: AKR7A3; Human Recombinant AKR7A3; Aldo-keto reductase family 7; member A 3; Aflatoxin B1 aldehyde reductase member 3; AFB1 aldehyde reductase 2(AFAR2).; AKR7A3 active protein

• Host: E Coli
• Purity/Purification: >=95%
• Form/Format: 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 10% glycerol.; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELE SRQLSRARPA TVLGAMEMGR RMDAPTSAAV TRAFLERGHT EIDTAFVYSE GQSETILGGL GLRLGGSDCR VKIDTKAIPL FGNSLKPDSL RFQLETSLKR LQCPRVDLFY LHMPDHSTPV EETLRACHQL HQEGKFVELG LSNYAAWEVA EICTLCKSNG WILPTVYQGM YNAITRQVET ELFPCLRHFG LRFYAFNPLA GGLLTGKYKY EDKDGKQPVG RFFGNTWAEM YRNRYWKEHH FEGIALVEKA LQAAYGASAP SMTSATLRWM YHHSQLQGAH GDAVILGMSS LEQLEQNLAA AEEGPLEPAV VDAFNQAWHL VAHECPNYFR
• Sequence Length: 331

• Applicable Applications for AKR7A3 active protein: SDS-PAGE
• Biological Activity: Specific activity is approximately > 0.1 units/mg
• Unit Definition: Specific activity is approximately > 0.1 units/mg. Enzymatic activity was confirmed by measuring the amount of enzyme catalyzing the oxidation of 1 micromole NADPH per minute at 25 degree C. Specific activity was expressed as units/mg protein.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for AKR7A3 active protein

Background: AKR7A3, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. It takes part in the detoxification of aldehydes and ketones. AKR7A3 reduces the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. AKR7A3 participates in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Product Categories/Family for AKR7A3 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)  

NCBI and Uniprot Product Information

• NCBI GI #: 41152114
• NCBI GeneID: 22977
• NCBI Accession #: NP_036199.2
• NCBI GenBank Nucleotide #: NM_012067.2
• UniProt Accession #: O95154; Q86SR4; Q8IVN6; Q8N5V6; Q8TAX1; Q9NUC3
• Molecular Weight: 41.6 kDa
• NCBI Official Full Name: aflatoxin B1 aldehyde reductase member 3
• NCBI Official Synonym Full Names: aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
• NCBI Official Symbol: AKR7A3
• NCBI Official Synonym Symbols: AFAR2
• NCBI Protein Information: aflatoxin B1 aldehyde reductase member 3
• UniProt Protein Name: Aflatoxin B1 aldehyde reductase member 3
• Protein Family: Aflatoxin B1 aldehyde reductase
• UniProt Gene Name: AKR7A3
• UniProt Synonym Gene Names: AFAR2; AFB1-AR 2
• UniProt Entry Name: ARK73_HUMAN

NCBI Description

Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004]

Uniprot Description

AKR7A3: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.

Protein type: EC 1.-.-.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytosol

Molecular Function: electron carrier activity; aldo-keto reductase activity

Biological Process: xenobiotic metabolic process; aldehyde metabolic process