Dual Specificity Phosphatase 10 Recombinant Protein | DUSP10 recombinant protein

Recombinant Human Dual Specificity Phosphatase 10

Cat. Num. AAA144528

• Gene Names: DUSP10; MKP5; MKP-5
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Dual Specificity Phosphatase 10; Recombinant Human Dual Specificity Phosphatase 10; DUSP10 Human; Dual Specificity Phosphatase 10 Human Recombinant; Dual specificity protein phosphatase 10; dual specificity phosphatase MKP-5; MKP-5; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; serine/threonine specific protein phosphatase; EC 3.1.3.16; EC 3.1.3.48; DUSP10 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The DUSP10 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol.; Sterile Filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMIIYPN DLAKKMTKCS KSHLPSQGPV IIDCRPFMEY NKSHIQGAVH INCADKISRR RLQQGKITVL DLISCREGKD SFKRIFSKEI IVYDENTNEP SRVMPSQPLH IVLESLKREG KEPLVLKGGL SSFKQNHENL CDNSLQLQEC REVGGGASAA SSLLPQPIPT TPDIENAELT PILPFLFLGN EQDAQDLDTM QRLNIGYVIN VTTHLPLYHY EKGLFNYKRL PATDSNKQNL RQYFEEAFEF IEEAHQCGKG LLIHCQAGVS RSATIVIAYL MKHTRMTMTD AYKFVKGKRP IISPNLNFMG QLLEFEEDLN NGVTPRILTP KLMGVETVV.
• Sequence Length: 482

Related Product Information for DUSP10 recombinant protein

Description: DUSP10 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 359 amino acids (149-482) and having a molecular mass of 40.4kDa.DUSP10 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Categories/Family for DUSP10 recombinant protein

Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 6005812
• NCBI GeneID: 11221
• NCBI Accession #: NP_009138.1
• NCBI GenBank Nucleotide #: NM_007207.5
• UniProt Accession #: Q9Y6W6; Q6GSI4; Q9H9Z5; D3DTB4
• Molecular Weight: 16,110 Da
• NCBI Official Full Name: dual specificity protein phosphatase 10
• NCBI Official Synonym Full Names: dual specificity phosphatase 10
• NCBI Official Symbol: DUSP10
• NCBI Official Synonym Symbols: MKP5; MKP-5
• NCBI Protein Information: dual specificity protein phosphatase 10; dual specificity phosphatase MKP-5; map kinase phosphatase 5; mitogen-activated protein kinase phosphatase 5; serine/threonine specific protein phosphatase
• UniProt Protein Name: Dual specificity protein phosphatase 10
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP10
• UniProt Synonym Gene Names: MKP5; MAP kinase phosphatase 5; MKP-5
• UniProt Entry Name: DUS10_HUMAN

NCBI Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus

Molecular Function: MAP kinase phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: negative regulation of oligodendrocyte differentiation; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of adaptive immune response; response to stress; JNK cascade; oligodendrocyte differentiation; response to lipopolysaccharide; protein amino acid dephosphorylation; inactivation of MAPK activity