Human dual specificity phosphatase 10 ELISA Kit | DUSP10 elisa kit

Human Dual specificity protein phosphatase 10, DUSP10 ELISA Kit

Cat. Num. AAA9341921

• Gene Names: DUSP10; MKP5; MKP-5
• Reactivity: Human
• Synonyms: dual specificity phosphatase 10; Human Dual specificity protein phosphatase 10; DUSP10 ELISA Kit; Human Dual specificity protein phosphatase 10 (DUSP10) ELISA kit; MKP-5; MKP5; dual specificity phosphatase MKP-5; map kinase phosphatase 5; serine/threonine specific protein phosphatase; DUSP10 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.25 ng/ml - 8 ng/ml
• Sensitivity: 0.1 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for DUSP10 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of DUSP10 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 6005812
• NCBI GeneID: 11221
• NCBI Accession #: NP_009138.1
• NCBI GenBank Nucleotide #: NM_007207.5
• UniProt Accession #: Q9Y6W6; Q6GSI4; Q9H9Z5; D3DTB4
• Molecular Weight: 52,642 Da
• NCBI Official Full Name: dual specificity protein phosphatase 10
• NCBI Official Synonym Full Names: dual specificity phosphatase 10
• NCBI Official Symbol: DUSP10
• NCBI Official Synonym Symbols: MKP5; MKP-5
• NCBI Protein Information: dual specificity protein phosphatase 10; map kinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 5
• UniProt Protein Name: Dual specificity protein phosphatase 10
• Protein Family: Dual specificity protein phosphatase
• UniProt Gene Name: DUSP10
• UniProt Synonym Gene Names: MKP5; MAP kinase phosphatase 5; MKP-5
• UniProt Entry Name: DUS10_HUMAN

NCBI Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus

Molecular Function: MAP kinase phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: negative regulation of oligodendrocyte differentiation; negative regulation of JNK activity; negative regulation of JNK cascade; regulation of adaptive immune response; response to stress; JNK cascade; oligodendrocyte differentiation; response to lipopolysaccharide; protein amino acid dephosphorylation; inactivation of MAPK activity