Typical Testing Data
Human Dual oxidase 2 ELISA Kit | DUOX2 elisa kit
Human Dual oxidase 2 ELISA Kit
Typical Testing Data
Typical Testing Data
Typical Standard Curve
Typical Standard Curve
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Uniprot Description
DUOX2: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6). A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 1.6.3.1; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: calcium ion binding; heme binding; NAD(P)H oxidase activity; peroxidase activity
Biological Process: adenohypophysis morphogenesis; bone mineralization; cuticle development; cytokine and chemokine mediated signaling pathway; fertilization; hormone biosynthetic process; hydrogen peroxide biosynthetic process; hydrogen peroxide catabolic process; inner ear development; multicellular organism growth; response to cAMP; response to oxidative stress; response to virus; thyroid gland development; thyroid hormone generation
Disease: Thyroid Dyshormonogenesis 6
Research Articles on DUOX2
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Product Notes
The Human DUOX2 duox2 (Catalog #AAA760924) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA760924 ELISA Kit recognizes Human DUOX2. It is sometimes possible for the material contained within the vial of "Dual oxidase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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