E3 ubiquitin-protein ligase DTX3L (Dtx3l) Recombinant Protein | Dtx3l recombinant protein
Recombinant Mouse E3 ubiquitin-protein ligase DTX3L (Dtx3l)
NCBI and Uniprot Product Information
Uniprot Description
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes.
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Product Notes
The Dtx3l dtx3l (Catalog #AAA1348519) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 2-748, Full length protein. The amino acid sequence is listed below: ASSPDPPSPL LVRLRESIPK AHRKLEIYFQ SRASGGGECS VQPVGPSAPD TYEVKFLKKA DKEKVLKKSE HEMLVHNKPV TIVLETTKKP VEDLRPRLPS LTQPVETPSS RPPSLTGSLD EALCDDIHPQ DGLVSNSVDS VVQKIFLAVT AELNCDLLSK EQRASITTVC PHIIKSMEGS DGIKKVCGNF KDIEKIHHFL SEQLLEREQK RKGSEQKRKC APQKHTPPDV EREPPDQSSI QVPVLLLEYF KHVNPGRLEF IEYKFGVNIE IQASSPNMVT VGFTSSPFGN VEEASQSFVR DFQKCSQSLK QDCISLEEHQ RAKEVRQELS RCFPKLLIKG QGRTLTLLGS PADISAATEK VSQGLGLRPV KITASGYTTG IEVDSTRFKL LEPELLQEIS EIEQKFNTRG KVQEKGQKTC ILFVPKDKDL DLSVQSYTGF TDAFQRATWQ LRTEVLSLKG LGKERARLHN TKFADNFKKE HPNVHFVTSQ ESVTLTGLPH HLAQAMQYVS KRMGLAPSSG EKLAMDQETP MEISSSDPHG DQQENAALPA PRGTSSSPAA SKGTEDYCVI CMDTISNKHV LPKCKHEFCT SCISKAMLIK PVCPVCLTSY GIQKGNQPEG TMSYSTQKGS LPGYEGCGTI VINYEIKDGI QTKEHPNPGK AYHGTRRTAY LPDNTEGRKV LDLLHEAFKH RLTFTIGYSR ATGVSDVITW NDIHHKTSKF GGPANFGYPD PDYLKRVKEE LKAKGIE. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase DTX3L (Dtx3l), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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