Mouse dystrobrevin binding protein 1 ELISA Kit | DTNBP1 elisa kit
Mouse Dysbindin, DTNBP1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DTNBP1: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16980328). Interacts with RNF151 and CMYA5. Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with TRIM32, AP3M1 and AP3B2. Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2). Interacts with the DNA-dependent protein kinase complex DNA-PK. Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3. Belongs to the dysbindin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle
Cellular Component: endoplasmic reticulum membrane; neuron projection; synaptic vesicle membrane; cell; endoplasmic reticulum; postsynaptic density; dendritic spine; postsynaptic membrane; growth cone; membrane; axon; cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; intracellular; sarcoplasm; cell junction; nucleus; sarcolemma; endosome
Molecular Function: protein binding
Biological Process: muscle development; organelle organization and biogenesis; response to stimulus; regulation of dopamine secretion; positive regulation of neurotransmitter secretion; platelet dense granule organization and biogenesis; regulation of dopamine receptor signaling pathway; actin cytoskeleton reorganization; anterograde synaptic vesicle transport; anterograde axon cargo transport; blood coagulation; neurite development; neurite morphogenesis
Research Articles on DTNBP1
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Product Notes
The Mouse DTNBP1 dtnbp1 (Catalog #AAA9328087) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328087 ELISA Kit recognizes Mouse DTNBP1. It is sometimes possible for the material contained within the vial of "dystrobrevin binding protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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