D(1B) dopamine receptor (Drd5) Recombinant Protein | Drd5 recombinant protein
Recombinant Rat D (1B) dopamine receptor (Drd5)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
dopamine receptor; may play a role in stimulation of adenylyl cyclase, activation of phospholipase C, and phosphatidylinositol phosphate metabolism in the central nervous system [RGD, Feb 2006]
Uniprot Description
DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass
Cellular Component: axon; brush border membrane; cell soma; dendrite; dendritic spine; integral to plasma membrane; nonmotile primary cilium; plasma membrane
Molecular Function: dopamine binding; dopamine D1 receptor-like receptor activity; dopamine receptor activity; drug binding; G-protein alpha-subunit binding; protein binding
Biological Process: associative learning; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, phospholipase C activating pathway; G-protein signaling, adenylate cyclase activating pathway; mating behavior; negative regulation of blood pressure; negative regulation of cell migration; negative regulation of NAD(P)H oxidase activity; negative regulation of protein kinase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; regulation of female receptivity; regulation of long-term neuronal synaptic plasticity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission, dopaminergic; transmission of nerve impulse; visual learning; wound healing
Research Articles on Drd5
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Product Notes
The Drd5 drd5 (Catalog #AAA7013913) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-475aa; Full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Drd5 drd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MLPPGRNRTA QPARLGLQRQ LAQVDAPAGS ATPLGPAQVV TAGLLTLLIV WTLLGNVLVC AAIVRSRHLR AKMTNIFIVS LAVSDLFVAL LVMPWKAVAE VAGYWPFGTF CDIWVAFDIM CSTASILNLC IISVDRYWAI SRPFRYERKM TQRVALVMVG LAWTLSILIS FIPVQLNWHR DKAGSQGQEG LLSNGTPWEE GWELEGRTEN CDSSLNRTYA ISSSLISFYI PVAIMIVTYT RIYRIAQVQI RRISSLERAA EHAQSCRSRG AYEPDPSLRA SIKKETKVFK TLSMIMGVFV CCWLPFFILN CMVPFCSSGD AEGPKTGFPC VSETTFDIFV WFGWANSSLN PIIYAFNADF RKVFAQLLGC SHFCFRTPVQ TVNISNELIS YNQDTVFHKE IATAYVHMIP NAVSSGDREV GEEEEEGPFD HMSQISPTTP DGDLAAESVW ELDCEEEVSL GKISPLTPNC FDKTA. It is sometimes possible for the material contained within the vial of "D(1B) dopamine receptor (Drd5), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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