Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Recombinant Protein | DPM2 recombinant protein

Recombinant Human Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2), partial

• Gene Names: DPM2; CDG1U
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2); Recombinant Human Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2); partial; DPM2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 84

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4503365
• NCBI GeneID: 8818
• NCBI Accession #: NP_003854.1
• NCBI GenBank Nucleotide #: NM_003863.3
• UniProt Accession #: O94777; Q5XKK9; Q6FGH3
• Molecular Weight: 9,312 Da
• NCBI Official Full Name: dolichol phosphate-mannose biosynthesis regulatory protein
• NCBI Official Synonym Full Names: dolichyl-phosphate mannosyltransferase subunit 2, regulatory
• NCBI Official Symbol: DPM2
• NCBI Official Synonym Symbols: CDG1U
• NCBI Protein Information: dolichol phosphate-mannose biosynthesis regulatory protein
• UniProt Protein Name: Dolichol phosphate-mannose biosynthesis regulatory protein
• Protein Family: Dolichol phosphate-mannose biosynthesis regulatory protein
• UniProt Gene Name: DPM2
• UniProt Synonym Gene Names: DPM synthase subunit 2

NCBI Description

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.