CHD1 (internal) Blocking Peptide | CHD1 blocking peptide

CHD1 (internal) Immunizing Peptide

Cat. Num. AAA425877

• Reactivity: Human, Mouse, Rat, Dog
• Synonyms: CHD1 (internal); CHD1 (internal) Immunizing Peptide; Goat Anti-CHD1 (C Terminus) Antibody; CHD1 antibody; chromodomain helicase DNA binding protein 1 antibody; DKFZp686E2337 antibody; CHD1 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog
• Form/Format: 100ug of dried peptide
• Sequence: C-EHKSTPEHTWSSRK
• Sequence Length: 14

• Corresponding Antibody: The peptide was used in the production of MBS421541 -
• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 68299795
• NCBI GeneID: 1105
• NCBI Accession #: NP_001261.2
• NCBI GenBank Nucleotide #: NM_001270.2
• UniProt Accession #: O14646; Q17RZ3
• Molecular Weight: 196,688 Da
• NCBI Official Full Name: chromodomain-helicase-DNA-binding protein 1
• NCBI Official Synonym Full Names: chromodomain helicase DNA binding protein 1
• NCBI Official Symbol: CHD1
• NCBI Protein Information: chromodomain-helicase-DNA-binding protein 1; CHD-1; ATP-dependent helicase CHD1
• UniProt Protein Name: Chromodomain-helicase-DNA-binding protein 1
• Protein Family: Chromodomain-helicase-DNA-binding protein
• UniProt Gene Name: CHD1
• UniProt Synonym Gene Names: CHD-1
• UniProt Entry Name: CHD1_HUMAN

NCBI Description

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity

By similarity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. Ref.8

Catalytic activity: ATP + H2O = ADP + phosphate.

Subunit structure: Component of the SAGA complex

By similarity. Interacts with BCLAF1, NCoR, SRP20 and SAFB

By similarity. Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1. Ref.4 Ref.7 Ref.8 Ref.15

Subcellular location: Nucleus. Cytoplasm

By similarity. Note: Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis

By similarity.

Domain: The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3). Ref.7

Sequence similarities: Belongs to the SNF2/RAD54 helicase family.Contains 2 chromo domains.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.