TRPM7 / LTRPC7 Blocking Peptide | TRPM7 blocking peptide
TRPM7 / LTRPC7 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein.
Protein type: Membrane protein, multi-pass; EC 2.7.11.1; Channel, cation; Kinase, protein; Protein kinase, atypical; Membrane protein, integral; ATYPICAL group; Alpha family; ChaK subfamily
Chromosomal Location of Human Ortholog: 15q21
Cellular Component: integral to membrane; plasma membrane; ruffle
Molecular Function: actin binding; ATP binding; calcium channel activity; metal ion binding; myosin binding; protein serine/threonine kinase activity
Biological Process: actomyosin structure organization and biogenesis; calcium-dependent cell-matrix adhesion; protein amino acid autophosphorylation; protein tetramerization
Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1
Research Articles on TRPM7
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Product Notes
The TRPM7 trpm7 (Catalog #AAA425263) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The TRPM7 / LTRPC7 Immunizing Peptide reacts with Human, Mouse, Rat, Dog, Pig and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-TKESESTN SVRLML. It is sometimes possible for the material contained within the vial of "TRPM7 / LTRPC7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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