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SDHAF1 blocking peptide

SDHAF1 Immunizing Peptide

Gene Names
SDHAF1; LYRM8
Reactivity
Human, Mouse, Dog
Synonyms
SDHAF1; SDHAF1 Immunizing Peptide; succinate dehydrogenase complex assembly factor 1; SDHAF1 blocking peptide
Ordering
For Research Use Only!
Reactivity
Human, Mouse, Dog
Form/Format
100ug of dried peptide
Sequence
C-HDSTGAPETRPDGR
Sequence Length
115
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
12,806 Da
NCBI Official Full Name
succinate dehydrogenase assembly factor 1, mitochondrial
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 1
NCBI Official Symbol
SDHAF1
NCBI Official Synonym Symbols
LYRM8
NCBI Protein Information
succinate dehydrogenase assembly factor 1, mitochondrial
UniProt Protein Name
Succinate dehydrogenase assembly factor 1, mitochondrial
UniProt Gene Name
SDHAF1
UniProt Synonym Gene Names
SDHAF1
UniProt Entry Name
SDHF1_HUMAN

NCBI Description

The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]

Uniprot Description

SDHAF1: Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable). Defects in SDHAF1 are a cause of mitochondrial complex II deficiency (MT-C2D); also known as SDH-defective infantile leukoencephalopathy. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. Belongs to the complex I LYR family. SDHAF1 subfamily.

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: mitochondrial matrix; mitochondrion

Biological Process: iron-sulfur cluster assembly

Disease: Mitochondrial Complex Ii Deficiency

Research Articles on SDHAF1

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Product Notes

The SDHAF1 sdhaf1 (Catalog #AAA426389) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The SDHAF1 Immunizing Peptide reacts with Human, Mouse, Dog and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-HDSTGAPE TRPDGR. It is sometimes possible for the material contained within the vial of "SDHAF1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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