Dog KIM-1 ELISA Kit | KIM-1 elisa kit

Dog KIM-1

Cat. Num. AAA564199

• Reactivity: Dog
• Synonyms: KIM-1; Dog KIM-1; KIM-1 elisa kit

• Reactivity: Dog
• Specificity: This ELISA is specific for the measurement of natural and recombinant irisin in various samples. It should also work in mouse, rat and monkey biological samples. It does not cross-react with FNDC4, human adiponectin, human Nampt, human RBP4, human clusterin, human leptin, human vaspin, human GPX3, human resistin, human ACE2, human Iipocalin-2, human ANGPTL3, human ANGPTL6, human DNER, human DLK1, human calreticulin, human IL-33, mouse Nampt, mouse clusterin, mouse vaspin, mouse resistin.
• Sequence Length: 307

• Samples: Serum, Plasma And Cell Culture Supernatant
• Detection Range: 0.001 ~g/ml-5 ~g/ml
• Sensitivity: 1 ng/ml
• Intra-assay Precision: Six samples of known concentrations of irisin were assayed in replicates 8 times to test precision within an assay
• Inter-assay Precision: Five samples of known concentration,s of irisin were assay,ed in 5 separate assays to test precision between assays.

Related Product Information for KIM-1 elisa kit

Intended Uses: The Irisin ELISA kit is to be used for the measurement of Irisin in serum, plasma and cell culture supernatant. The sample material can be of human, mouse, rat, or of monkey origin. This ELISA kit is for research use only!!Background/Introduction: Fibronectin type III domain containing (FNDC)'family consists of the multiple protein species but has a typified fibronectin type III domain (1-2). Among them FNDC5 also called irisin, hereinafter named irisin, has been identified a myokine which is capable of inducing browning of white adipose tissue leading to brown adipocytes and beige fat cells by stimulating UCP1 expression, via the PGC-1a transcriptional co-activator (3). Irisin is a single-pass type I membrane protein whose secretion could be by a putative signal peptide. Since irisin has been discovered as a soluble protein from the culture supernatant of the myocytes from the muscle-specific PGC-1a transgenic mice the predicted extracellular domain should be cleaved followed by being liberated from the cell surface membrane. Indeed, this was the case by having shown that the presence of the irisin exists in the culture supernatants and human/mouse sera as a 22 kDa protein (3). Irisin is able to induce UCP1 as well as a number of genes manifested in brown adipose tissues. In particular, the level of irisin was increased by muscular exercise in mouse and human, suggesting that irisin plays an important role in obesity and glucose homeostasis.

NCBI and Uniprot Product Information

• NCBI GI #: 2665892
• Molecular Weight: 33,964 Da
• NCBI Official Full Name: kidney injury molecule-1
• UniProt Protein Name: Hepatitis A virus cellular receptor 1 homolog
• UniProt Gene Name: Havcr1
• UniProt Synonym Gene Names: Kim1; HAVcr-1; KIM-1; TIMD-1
• UniProt Entry Name: HAVR1_RAT

Uniprot Description

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair ().