Human dedicator of cytokinesis 3 ELISA Kit | DOCK3 elisa kit
Human DediCator of cytokinesis protein 3, DOCK3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Uniprot Description
DOCK3: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Belongs to the DOCK family.
Protein type: GEFs; GEFs, misc.; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component: cytoplasm
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process: small GTPase mediated signal transduction; positive regulation of GTPase activity
Research Articles on DOCK3
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Product Notes
The Human DOCK3 dock3 (Catalog #AAA9319084) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319084 ELISA Kit recognizes Human DOCK3. It is sometimes possible for the material contained within the vial of "dedicator of cytokinesis 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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