Cyclin-D-binding Myb-like transcription factor 1 (Dmtf1) Recombinant Protein | Dmtf1 recombinant protein

Recombinant Mouse Cyclin-D-binding Myb-like transcription factor 1 (Dmtf1)

Cat. Num. AAA1412437

• Gene Names: Dmtf1; Dimp; Dmp1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclin-D-binding Myb-like transcription factor 1 (Dmtf1); Recombinant Mouse Cyclin-D-binding Myb-like transcription factor 1 (Dmtf1); Dmtf1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-761, Full length protein
• Sequence: MSTVEEDSDTVTVETVNSVTFTQDTDGNLILHCPQNDPDEVDSEDSTEPPHKRLCLSSEDDQSIDDATPCISVVALPLSENDQSFEVTMTATTEVADDELSEGTVTQIQILQNDQLDEISPLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDNTAISPSPMAALQIPVQITHVSSTDSPAASVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTTNPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSLSQEELTVDSDLHSSDFPEPPDALEADTFPDEIPRPKMTIQPSFNNAHVSKFSDQNSTELMNSVMVRTEEEIADTDLKQEEPPSDLASAYVTEDLESPTIVHQVHQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPIFQHHQEASNIIGSSLGSPVSEDSKDVEDLVNCH
• Sequence Length: 761

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Dmtf1 recombinant protein

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 160333146
• NCBI GeneID: 23857
• NCBI Accession #: NP_001103797.1
• NCBI GenBank Nucleotide #: NM_001110327.1
• UniProt Accession #: Q8CE22; P70413; Q3TUR9; Q80VR8; Q8BQX6; Q8CA56; Q8CCZ0
• Molecular Weight: 31,373 Da
• NCBI Official Full Name: cyclin-D-binding Myb-like transcription factor 1 isoform 2
• NCBI Official Synonym Full Names: cyclin D binding myb-like transcription factor 1
• NCBI Official Symbol: Dmtf1
• NCBI Official Synonym Symbols: Dimp; Dmp1
• NCBI Protein Information: cyclin-D-binding Myb-like transcription factor 1
• UniProt Protein Name: Cyclin-D-binding Myb-like transcription factor 1
• Protein Family: Cyclin-D-binding Myb-like transcription factor
• UniProt Gene Name: Dmtf1
• UniProt Synonym Gene Names: Dmp1; mDmp1

Uniprot Description

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.