Rabbit anti-Human DMTF1 Polyclonal Antibody | anti-DMTF1 antibody

DMTF1 Polyclonal Antibody

Cat. Num. AAA9141034

• Gene Names: DMTF1; DMP1; DMTF; MRUL; hDMP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: DMTF1; Polyclonal Antibody; DMTF1 Polyclonal Antibody; DMP1; DMTF; MRUL; hDMP1; cyclin-D-binding Myb-like transcription factor 1; anti-DMTF1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 3.38 mg/ml (varies by lot)
• Sequence Length: 672

• Applicable Applications for anti-DMTF1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 561-760 of human DMTF1 (NP_066968.3).
• Immunogen Sequence: VTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot-DMTF1 Polyclonal Antibody)

Related Product Information for anti-DMTF1 antibody

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 215599981
• NCBI GeneID: 9988
• NCBI Accession #: NP_001135798
• NCBI GenBank Nucleotide #: NP_001135798.1
• UniProt Accession #: Q9Y222
• NCBI Official Full Name: cyclin-D-binding Myb-like transcription factor 1 isoform b
• NCBI Official Synonym Full Names: cyclin D binding myb like transcription factor 1
• NCBI Official Symbol: DMTF1
• NCBI Official Synonym Symbols: DMP1; DMTF; MRUL; hDMP1
• NCBI Protein Information: cyclin-D-binding Myb-like transcription factor 1
• UniProt Protein Name: Cyclin-D-binding Myb-like transcription factor 1
• Protein Family: Cyclin-D-binding Myb-like transcription factor
• UniProt Gene Name: DMTF1
• UniProt Synonym Gene Names: DMP1; hDMTF1; hDMP1
• UniProt Entry Name: DMTF1_HUMAN

NCBI Description

This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]