Doublesex- and mab-3-related transcription factor 1 (DMRT1) Recombinant Protein | DMRT1 recombinant protein
Recombinant Pig Doublesex- and mab-3-related transcription factor 1 (DMRT1)
Gene Names
DMRT1; DMRT-1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Doublesex- and mab-3-related transcription factor 1 (DMRT1); Recombinant Pig Doublesex- and mab-3-related transcription factor 1 (DMRT1); DMRT1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-373, Full length protein
Sequence
MPNDDAYSKPSAPSEAPHAPGPPPQGKAGGFSKALLGTSGGGGSGGSSGGGSGASGMSAASNKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENHGSNPCLMTESSSSSQPPPPPPAASTPTTAAPEGRMVIQDIPAVTSRGHVENAPDLVSDSTYYSSFYQPSLFPYYNNLYNYPQYSMALAADSSSGDVGNALGGSPVKNSLRGLPAPYVPGQTGNQWQMKNSETRHAVSSQYRMHSYYPPPSYLGQSVSQIFTFEDGPSYSEAKASVLSPPSSQDSGLVSLSSSSPISNESTKGVLECESASEPSSFPVTPVIEERTK
Sequence Length
373
Species
Sus scrofa (Pig)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for DMRT1 recombinant protein
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,346 Da
NCBI Official Full Name
doublesex- and mab-3-related transcription factor 1
NCBI Official Symbol
DMRT1
NCBI Official Synonym Symbols
DMRT-1
NCBI Protein Information
doublesex- and mab-3-related transcription factor 1
UniProt Protein Name
Doublesex- and mab-3-related transcription factor 1
Protein Family
UniProt Gene Name
DMRT1
Uniprot Description
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis ().
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Product Notes
The DMRT1 dmrt1 (Catalog #AAA1476362) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-373, Full length protein. The amino acid sequence is listed below: MPNDDAYSKP SAPSEAPHAP GPPPQGKAGG FSKALLGTSG GGGSGGSSGG GSGASGMSAA SNKKSPRLPK CARCRNHGYA SPLKGHKRFC MWRDCQCKKC NLIAERQRVM AAQVALRRQQ AQEEELGISH PIPLPSAAEL LVKRENHGSN PCLMTESSSS SQPPPPPPAA STPTTAAPEG RMVIQDIPAV TSRGHVENAP DLVSDSTYYS SFYQPSLFPY YNNLYNYPQY SMALAADSSS GDVGNALGGS PVKNSLRGLP APYVPGQTGN QWQMKNSETR HAVSSQYRMH SYYPPPSYLG QSVSQIFTFE DGPSYSEAKA SVLSPPSSQD SGLVSLSSSS PISNESTKGV LECESASEPS SFPVTPVIEE RTK. It is sometimes possible for the material contained within the vial of "Doublesex- and mab-3-related transcription factor 1 (DMRT1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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