Hamster Distal Less Homeobox 5 ELISA Kit | DLX5 elisa kit
Hamster Distal Less Homeobox 5 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family.
Protein type: Transcription factor; DNA-binding
Cellular Component: nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding
Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; ossification; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; olfactory pit development; ear development; palate development; osteoblast differentiation; BMP signaling pathway; cell proliferation; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; axonogenesis; epithelial cell differentiation; anatomical structure formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; endochondral ossification; embryonic limb morphogenesis
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Product Notes
The Hamster DLX5 (Catalog #AAA018748) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA018748 ELISA Kit recognizes Hamster DLX5. It is sometimes possible for the material contained within the vial of "Distal Less Homeobox 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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