Mouse dickkopf homolog 1 (Xenopus laevis) ELISA Kit | DKK1 elisa kit
Mouse Dickkopf-related protein 1, DKK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; plasma membrane; extracellular region
Molecular Function: protein binding; receptor antagonist activity; low-density lipoprotein receptor binding
Biological Process: cellular morphogenesis during differentiation; negative regulation of skeletal muscle development; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; response to retinoic acid; regulation of receptor internalization; multicellular organismal development; regulation of Wnt receptor signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; mesoderm formation; negative regulation of mesodermal cell fate specification; hair follicle development; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis; endoderm development
Research Articles on DKK1
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Product Notes
The Mouse DKK1 dkk1 (Catalog #AAA924527) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA924527 ELISA Kit recognizes Mouse DKK1. It is sometimes possible for the material contained within the vial of "dickkopf homolog 1 (Xenopus laevis), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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