Exosome complex exonuclease RRP44 (Dis3) Recombinant Protein | Dis3 recombinant protein
Recombinant Mouse Exosome complex exonuclease RRP44 (Dis3) , partial
NCBI and Uniprot Product Information
Uniprot Description
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
Research Articles on Dis3
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Product Notes
The Dis3 dis3 (Catalog #AAA1417656) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 427-842. Partial. The amino acid sequence is listed below: ETETEVLLLE HDVPHQPFSQ AVLSFLPRMP WSITEEDMKN REDLRHLCVC SVDPPGCTDI DDALHCRELS NGNLEVGVHI ADVSHFIRPG NALDQESARR GTTVYLCEKR IDMVPELLSS NLCSLRSNVD RLAFSCIWEM NHNAEILKTR FTKSVINSKA SLTYAEAQMR IDSAAMNDDI TTSLRGLNQL AKILKKGRIE KGALTLSSPE IRFHMDSETH DPIDLQTKEL RETNSMVEEF MLLANISVAK KIHEEFSEHA LLRKHPAPPP SNYDILVKAA KSKNLQIKTD TAKSLADSLD RAESPDFPYL NTLLRILATR CMMQAVYFCS GMDNDFHHYG LASPIYTHFT SPIRRYADII VHRLLAVAIG ADCTYPELTD KHKLSDICKN LNFRHKMAQY AQRASVAFHT QLFFKS . It is sometimes possible for the material contained within the vial of "Exosome complex exonuclease RRP44 (Dis3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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