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Dihydroorotate dehydrogenase (quinone) (Dhodh) Recombinant Protein | Dhodh recombinant protein
Recombinant Mouse Dihydroorotate dehydrogenase (quinone), mitochondrial (Dhodh)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
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NCBI and Uniprot Product Information
Uniprot Description
DHODH: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS); also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Protein type: Oxidoreductase; Nucleotide Metabolism - pyrimidine; EC 1.3.5.2; Membrane protein, integral; Mitochondrial
Cellular Component: cell soma; cytoplasm; integral to membrane; membrane; mitochondrial inner membrane; mitochondrion; nucleoplasm
Molecular Function: catalytic activity; dihydroorotate dehydrogenase activity; drug binding; FMN binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; ubiquinone binding
Biological Process: 'de novo' pyrimidine base biosynthetic process; positive regulation of apoptosis; pyrimidine nucleotide biosynthetic process
Research Articles on Dhodh
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Product Notes
The Dhodh dhodh (Catalog #AAA7013763) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 11-395aa; Full Length of Mature Protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Dhodh dhodh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: LDAAIILGGG GLLFTSYLTA TGDDHFYAEY LMPALQRLLD PESAHRLAVR VISLGLLPRA TFQDSNMLEV RVLGHKFRNP VGIAAGFDKH GEAVDGLYKL GFGFVEVGSV TPQPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSAVEHRL RARQQKQTQL TTDGLPLGIN LGKNKTSVDA AADYVEGVRI LGPLADYLVV NVSSPNTAGL RSLQGKTELR RLLSKVLQER DALKGPQKPA VLVKIAPDLT AQDKEDIASV ARELGIDGLI ITNTTVSRPV GLQGALRSET GGLSGKPLRD LSTQTIREMY ALTQGTIPII GVGGVSSGQD ALEKIQAGAS LVQLYTALTF LGPPVVARVK RELEALLKER GFNTVTDAIG VDHRR. It is sometimes possible for the material contained within the vial of "Dihydroorotate dehydrogenase (quinone) (Dhodh), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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