Desert hedgehog protein (DHH) Recombinant Protein | DHH recombinant protein

Recombinant Human Desert hedgehog protein (DHH)

Cat. Num. AAA1054194

• Gene Names: DHH; GDXYM; HHG-3; SRXY7
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Desert hedgehog protein (DHH); Recombinant Human Desert hedgehog protein (DHH); DHH recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 23-396, Full length protein
• Sequence: CGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG
• Sequence Length: 374

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for DHH recombinant protein

This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

NCBI and Uniprot Product Information

• NCBI GI #: 19482158
• NCBI GeneID: 50846
• NCBI Accession #: NP_066382.1
• NCBI GenBank Nucleotide #: NM_021044.3
• UniProt Accession #: O43323; Q15794
• Molecular Weight: 43,577 Da
• NCBI Official Full Name: desert hedgehog protein preproprotein
• NCBI Official Synonym Full Names: desert hedgehog
• NCBI Official Symbol: DHH
• NCBI Official Synonym Symbols: GDXYM; HHG-3; SRXY7
• NCBI Protein Information: desert hedgehog protein
• UniProt Protein Name: Desert hedgehog protein
• Protein Family: Desert hedgehog protein
• UniProt Gene Name: DHH
• UniProt Synonym Gene Names: DHH

NCBI Description

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010]

Uniprot Description

Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.