Delta-conotoxin EVIA Recombinant Protein | Delta-EVIA recombinant protein
Recombinant Conus ermineus Delta-conotoxin EVIA
NCBI and Uniprot Product Information
Uniprot Description
Function: Delta-conotoxins bind to site 6 of voltage-gated sodium channels and inhibit the inactivation process. This toxin inhibits sodium channel inactivation in neuronal membranes from amphibians and mammals (Nav1.2a/SCN1A, Nav1.3/SCN3A and Nav1.6/SCN8A) upon binding to receptor site 6, without affecting rat skeletal muscle (Nav1.4/SCN4A) and human cardiac muscle (Nav1.5/SCN5A) sodium channels.
Subcellular location: Secreted Ref.1 Ref.2.
Tissue specificity: Expressed by the venom duct. Ref.1 Ref.2
Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.The cysteine framework is VI/VII (C-C-CC-C-C).
Toxic dose: Dose that produces hyperactivity (ED(50)) is 1.8 pmol/g body mass (native toxin), 1.9 pmol/g body mass (synthetic toxin) and 3.9 pmol/g body mass (P13A mutant).
Miscellaneous: Exists in two forms, due to cis-trans isomerization at 12-Leu-Pro-13.
Sequence similarities: Belongs to the conotoxin O1 superfamily.
Caution: Another delta-conotoxin was named EVIA in 2001, but this toxin was renamed EVIB.
Mass spectrometry: Molecular mass is 3288.3 Da from positions 1 - 32. Determined by ESI. Ref.1
Similar Products
Product Notes
The Delta-conotoxin EVIA delta-evia (Catalog #AAA1117042) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-32aa; Cytoplasmic domain. The amino acid sequence is listed below: DDCIKPYGFC SLPILKNGLC CSGACVGVCA DL. It is sometimes possible for the material contained within the vial of "Delta-conotoxin EVIA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
