Defensin alpha 3/DEFA3 Recombinant Protein | DEFA3 recombinant protein

Defensin alpha 3/DEFA3 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121810

• Gene Names: DEFA3; HP3; DEF3; HNP3; HP-3; HNP-3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Defensin alpha 3/DEFA3; Defensin alpha 3/DEFA3 Protein; Human; Recombinant (hFc Tag); Human DEFA3 Protein (Fc Tag); DEF3 Protein; HNP-3 Protein; HNP3 Protein; HP-3 Protein; HP3 Protein; defensin alpha 3; DEFA3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Asp39-Cys94

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Glu
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human DEFA3 (NP_005208.1)(Asp39-Cys94) was expressed with the Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 4885179
• NCBI GeneID: 1668
• NCBI Accession #: NP_005208.1
• NCBI GenBank Nucleotide #: NM_005217.3
• UniProt Accession #: P59666; P11479; Q14125
• Molecular Weight: 10,245 Da
• NCBI Official Full Name: neutrophil defensin 3 preproprotein
• NCBI Official Synonym Full Names: defensin alpha 3
• NCBI Official Symbol: DEFA3
• NCBI Official Synonym Symbols: HP3; DEF3; HNP3; HP-3; HNP-3
• NCBI Protein Information: neutrophil defensin 3
• UniProt Protein Name: Neutrophil defensin 3
• Protein Family: Alpha-defensin
• UniProt Gene Name: DEFA3
• UniProt Synonym Gene Names: DEF3; HP-3; HP3; HP-2; HP2

NCBI Description

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]

Uniprot Description

Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.