Probable ATP-dependent RNA helicase DDX60 (DDX60) Recombinant Protein | DDX60 recombinant protein

Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Probable ATP-dependent RNA helicase DDX60 (DDX60); Recombinant Human Probable ATP-dependent RNA helicase DDX60 (DDX60); partial; DDX60 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1712

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 222831595
• NCBI GeneID: 55601
• NCBI Accession #: NP_060101.3
• NCBI GenBank Nucleotide #: NM_017631.5
• UniProt Accession #: Q8IY21; Q6PK35; Q9NVE3
• Molecular Weight: 197,853 Da
• NCBI Official Full Name: probable ATP-dependent RNA helicase DDX60
• NCBI Official Synonym Full Names: DExD/H-box helicase 60
• NCBI Official Symbol: DDX60
• NCBI Protein Information: probable ATP-dependent RNA helicase DDX60
• UniProt Protein Name: Probable ATP-dependent RNA helicase DDX60
• Protein Family: Probable ATP-dependent RNA helicase
• UniProt Gene Name: DDX60

NCBI Description

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]

Uniprot Description

Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).