Discoidin domain-containing receptor 2 (Ddr2) Recombinant Protein | Ddr2 recombinant protein

Recombinant Mouse Discoidin domain-containing receptor 2 (Ddr2), partial

Cat. Num. AAA1456748

• Gene Names: Ddr2; Ntrkr3; tyro10; AW495251
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Discoidin domain-containing receptor 2 (Ddr2); Recombinant Mouse Discoidin domain-containing receptor 2 (Ddr2); partial; Ddr2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-399
• Sequence: KAQVNPAIC RYPLGMSGGH IPDEDITASS QWSESTAAKY GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV GTQGRHAGGH GIEFAPMYKI NYSRDGSRWI SWRNRHGKQV LDGNSNPYDV FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD DFTQTHEYHV WPGYDYVGWR NESATNGFIE IMFEFDRIRN FTTMKVHCNN MFAKGVKIFK EVQCYFRSEA SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS EITFQSDAAM YNNSGALPTS PMAPTTYDPM LKVDDSNTR
• Sequence Length: 378

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ddr2 recombinant protein

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein.

NCBI and Uniprot Product Information

• NCBI GI #: 158508514
• NCBI GeneID: 18214
• NCBI Accession #: NP_072075.2
• NCBI GenBank Nucleotide #: NM_022563.2
• UniProt Accession #: Q62371; B2RSD7
• Molecular Weight: 96,482 Da
• NCBI Official Full Name: discoidin domain-containing receptor 2
• NCBI Official Synonym Full Names: discoidin domain receptor family, member 2
• NCBI Official Symbol: Ddr2
• NCBI Official Synonym Symbols: Ntrkr3; tyro10; AW495251
• NCBI Protein Information: discoidin domain-containing receptor 2
• UniProt Protein Name: Discoidin domain-containing receptor 2
• Protein Family: Discoidin domain-containing receptor
• UniProt Gene Name: Ddr2
• UniProt Synonym Gene Names: Ntrkr3; Tkt; Tyro10; Discoidin domain receptor 2

Uniprot Description

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.