Mouse dynactin 1 (p150, glued homolog, Drosophila) ELISA Kit | DCTN1 elisa kit
Mouse Dynactin subunit 1, DCTN1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
dynactin 1: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors. Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. Belongs to the dynactin 150 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Motor; Motility/polarity/chemotaxis
Cellular Component: spindle pole; centrosome; microtubule; protein complex; cytoplasmic dynein complex; cell; retromer complex; leading edge; kinetochore; dynein complex; dynactin complex; cytoskeleton; membrane; cytoplasm
Molecular Function: dynein binding; protein binding; motor activity
Biological Process: transport; melanosome transport; retrograde transport, endosome to Golgi
Research Articles on DCTN1
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Product Notes
The Mouse DCTN1 dctn1 (Catalog #AAA9340886) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340886 ELISA Kit recognizes Mouse DCTN1. It is sometimes possible for the material contained within the vial of "dynactin 1 (p150, glued homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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