p50 Dynamitin ELISA Kit | DCTN-50 elisa kit
p50 Dynamitin Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Description
dynactin 2: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: centrosome; cytoplasm; cytosol; dynactin complex; dynein complex; extracellular exosome; growth cone; kinetochore; membrane; microtubule; vesicle
Molecular Function: identical protein binding; motor activity; protein binding; protein kinase binding; spectrin binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; melanosome transport; mitotic cell cycle; mitotic spindle organization and biogenesis; protein localization to centrosome; regulation of G2/M transition of mitotic cell cycle
Research Articles on DCTN-50
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Product Notes
The Human, Mouse, Rat DCTN-50 dctn2 (Catalog #AAA9500446) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9500446 ELISA Kit recognizes Human, Mouse, Rat DCTN-50. It is sometimes possible for the material contained within the vial of "p50 Dynamitin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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